Adriano Aguzzi Selected Research

Prions

1/2022	Glial activation in prion diseases is selectively triggered by neuronal PrPSc.
11/2021	Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
10/2021	Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference.
1/2021	Loss of PIKfyve drives the spongiform degeneration in prion diseases.
1/2021	Scaling analysis reveals the mechanism and rates of prion replication in vivo.
1/2021	The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.
1/2021	The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis.
10/2020	Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.
1/2020	Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease.
1/2020	Genome-wide transcriptomics identifies an early preclinical signature of prion infection.

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Adriano Aguzzi Research Topics

Disease

101	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2022 - 10/2000
53	Infections 02/2022 - 01/2002
33	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2021 - 07/2004
29	Scrapie 01/2021 - 01/2002
21	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2021 - 01/2002
20	Alzheimer Disease (Alzheimer's Disease) 05/2021 - 05/2003
8	Bovine Spongiform Encephalopathy (Mad Cow Disease) 01/2021 - 07/2004
8	Sporadic Creutzfeldt-Jakob Disease 01/2015 - 11/2003
7	Inflammation (Inflammations) 11/2017 - 02/2005
6	Proteostasis Deficiencies 11/2021 - 12/2008
6	Neoplasms (Cancer) 10/2018 - 04/2004
5	COVID-19 01/2022 - 02/2021
5	Amyloid Plaque 11/2021 - 01/2008
5	Disease Progression 01/2021 - 11/2010
5	Parkinson Disease (Parkinson's Disease) 01/2021 - 01/2002
5	Neuroinflammatory Diseases 01/2021 - 11/2017
5	Amyloidosis 06/2013 - 08/2009
4	Neuroblastoma 01/2019 - 07/2005
4	Gliosis 01/2019 - 04/2004
4	Chronic Wasting Disease 01/2014 - 07/2004
4	Brain Diseases (Brain Disorder) 09/2011 - 06/2004
3	Tauopathies 05/2021 - 01/2012
3	Communicable Diseases (Infectious Diseases) 01/2019 - 06/2004
2	Cognitive Dysfunction 01/2022 - 11/2012
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021 - 02/2005
2	Kuru 11/2018 - 01/2009
2	Polyneuropathies (Polyneuropathy) 01/2016 - 03/2010
2	Dementia (Dementias) 01/2015 - 10/2012
2	Disease Susceptibility (Diathesis) 07/2012 - 01/2009
2	Seizures (Absence Seizure) 07/2010 - 09/2007
2	Hepatocellular Carcinoma (Hepatoma) 10/2009 - 01/2002
2	Astrocytoma (Pilocytic Astrocytoma) 04/2004 - 05/2002
2	Glioma (Gliomas) 04/2004 - 05/2002
1	Critical Illness (Critically Ill) 01/2022
1	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 12/2021
1	Thrombosis (Thrombus) 12/2021
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2021
1	Cerebral Hemorrhage 01/2021
1	Hypertrophy 01/2021
1	Hematoma 01/2021
1	Crush Injuries 01/2021
1	Autoimmune Diseases (Autoimmune Disease) 10/2020

Drug/Important Bio-Agent (IBA)

96	PrionsIBA 01/2022 - 10/2000
81	Prion ProteinsIBA 11/2021 - 03/2002
42	Proteins (Proteins, Gene)FDA Link 02/2022 - 01/2002
18	AntibodiesIBA 01/2022 - 05/2002
16	Protein Isoforms (Isoforms)IBA 12/2019 - 04/2003
11	Amyloid (Amyloid Fibrils)IBA 11/2017 - 01/2008
8	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 06/2004
6	Biomarkers (Surrogate Marker)IBA 11/2017 - 06/2006
5	tau Proteins (tau Protein)IBA 05/2021 - 09/2002
5	Messenger RNA (mRNA)IBA 01/2020 - 05/2002
5	Amyloid beta-PeptidesIBA 08/2010 - 02/2005
4	AutoantibodiesIBA 02/2022 - 11/2012
4	LigandsIBA 11/2021 - 07/2013
4	Codon (Codons)IBA 10/2020 - 06/2002
4	CytokinesIBA 01/2019 - 04/2004
3	Immunoglobulin G (IgG)IBA 02/2021 - 01/2009
3	SynucleinsIBA 01/2021 - 12/2018
3	Endopeptidase K (Proteinase K)IBA 01/2020 - 01/2016
3	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2017 - 12/2014
3	Indicators and Reagents (Reagents)IBA 01/2017 - 06/2004
3	Protein AggregatesIBA 01/2016 - 01/2002
3	Peptides (Polypeptides)IBA 11/2014 - 02/2005
3	Lymphotoxin-alpha (Lymphotoxin)IBA 11/2012 - 12/2008
2	Prothrombin (Factor II)IBA 02/2022 - 12/2021
2	EnzymesIBA 01/2021 - 11/2017
2	Amyloidogenic ProteinsIBA 12/2018 - 02/2005
2	RNA (Ribonucleic Acid)IBA 10/2018 - 10/2006
2	Monoclonal AntibodiesIBA 01/2018 - 11/2012
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2017 - 02/2015
2	LipidsIBA 11/2017 - 11/2012
2	Nucleic AcidsIBA 11/2017 - 01/2008
2	Pharmaceutical PreparationsIBA 11/2017 - 01/2016
2	Complement Receptors (Complement Receptor)IBA 11/2017 - 11/2012
2	Everolimus FDA Link 01/2017 - 01/2016
2	Cell Surface ReceptorsIBA 05/2015 - 11/2014
2	14-3-3 Proteins (14-3-3 Protein)IBA 10/2012 - 10/2009
2	ThiophenesIBA 02/2010 - 08/2009
2	Phosphopyruvate Hydratase (Enolase)IBA 10/2009 - 05/2005
2	Type I Tumor Necrosis Factor ReceptorsIBA 06/2008 - 01/2002
2	Transcription Factors (Transcription Factor)IBA 07/2004 - 04/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2002 - 01/2002
1	Antiviral Agents (Antivirals)IBA 01/2022
1	AntigensIBA 01/2022
1	Antiphospholipid AntibodiesIBA 12/2021
1	Carrier Proteins (Binding Protein)IBA 12/2021
1	Cardiolipins (Cardiolipin)IBA 12/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 12/2021
1	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 12/2021
1	Neutralizing AntibodiesIBA 07/2021
1	Immunoglobulin A (IgA)IBA 02/2021
1	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 01/2021
1	CollagenIBA 01/2021
1	AcyltransferasesIBA 01/2021
1	Fingolimod Hydrochloride (FTY720)FDA Link 01/2021
1	SphingolipidsIBA 10/2020

Therapy/Procedure

9	Therapeutics 01/2020 - 07/2004
3	Blood Transfusion (Blood Transfusions) 01/2019 - 06/2006
3	Immunotherapy 01/2016 - 10/2004